Anticancer mechanism of Pisangulin angulata through in silico as teaching material

SANTOSO, AGUS MUJI and PRIMANDIRI, POPPY RAHMATIKA Anticancer mechanism of Pisangulin angulata through in silico as teaching material. Jurnal Biosfer, 12 (1). pp. 45-57. ISSN E-ISSN: 2614-3984

[img] Text

Download (11MB)
[img] Text
84205_0713088605_peer review.pdf

Download (571kB)
[img] Text

Download (11MB)
[img] Text

Download (3MB)
Official URL:


This study aims to reveal the anticancer mechanism of the bioactive compound of Pisangulin angulata and to assess the feasibility of that results as teaching material. This research includes descriptive explorations. In the first stage, an in silico analysis was performed by molecular docking method between physalin compounds and GLI1 protein. The second steps of this study aim to develop teaching materials based research using the Analysis, Reorganizing, Piloting Class, and Evaluating (ARPE models). Feasibility test was carried out by experts and practitioners. Think Pair Share was used in the pilot project. Student motivation and misconception were recorded using SMI and CRI instrument. This study reveals that physalin B has higher activities than controls. The type of chemical bond that is formed between GLI1 amino acids residues with physalin is hydrogen bonds and hydrophobic bonds. The visualization of the types of bonds in that molecular docking between GLI1 amino acid residues and physalin has a high degree of feasibility (89) and can be used to enrich Chemistry for Biology lectures. The visualization of these chemical bonds can increase learning motivation and can improve the understanding of the concept of chemical bonds.

Item Type: Article
Subjects: 710 Education science > 771 Biology education
Divisions: Fakultas Ilmu Kesehatan dan Sains > S1-Pendidikan Biologi
Depositing User: Agus Muji Santoso
Date Deposited: 10 Jan 2022 10:52
Last Modified: 10 Jan 2022 10:52

Actions (login required)

View Item View Item